Back to Search
Start Over
Role of prednisolone treatment in severeMycoplasma pneumoniae pneumonia in children
- Source :
- Pediatric Pulmonology. 41:263-268
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Mycoplasma pneumoniae pneumonia (MP) is responsible for 10-40% of cases of pediatric community-acquired pneumonia. Occasionally, progression to severe pneumonia occurs despite appropriate antibiotic therapy. We retrospectively evaluated the effect of prednisolone in 15 children with MP whose clinical and radiographic course worsened despite broad-spectrum antibiotics, including appropriate macrolides. The mean ( +/- SD) age was 6.1 +/- 1.9 years, and 10 were boys. All children had received macrolides at presentation, but they had persistent fever and progressively worsening radiographic findings. In addition to broad-spectrum antimicrobial therapy, we added prednisolone (1 mg/kg for 3-7 days, then tapered over 7 days) on day 6 (+/-1.5 days) of admission. Fourteen children became afebrile within 24 hr, and their clinical status and radiographic findings improved over several days. The white blood cell count at presentation was 7,500 +/- 2,000/mm3, with a proportion demonstrating lymphopenia (lymphocyte differential, 19.7 +/- 5.7%). In conclusion, corticosteroid treatment appeared to be temporally associated with clinical and radiographic improvement, and may be helpful for reducing morbidity in children with macrolide-nonresponsive severe MP. Further studies may be warranted.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Mycoplasma pneumoniae
Adolescent
medicine.drug_class
Prednisolone
Antibiotics
medicine.disease_cause
Risk Assessment
Severity of Illness Index
Drug Administration Schedule
Pharmacotherapy
White blood cell
Internal medicine
Pneumonia, Mycoplasma
medicine
Humans
Child
Retrospective Studies
Antibacterial agent
Dose-Response Relationship, Drug
business.industry
Respiratory disease
medicine.disease
Surgery
Pneumonia
Treatment Outcome
medicine.anatomical_structure
Child, Preschool
Pediatrics, Perinatology and Child Health
Drug Therapy, Combination
Female
Radiography, Thoracic
Macrolides
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 10990496 and 87556863
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Pediatric Pulmonology
- Accession number :
- edsair.doi.dedup.....60ac441206045c519ae12afba4c9713d