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Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases
- Source :
- Langmuir : the ACS journal of surfaces and colloids. 34(31)
- Publication Year :
- 2018
-
Abstract
- Encapsulation and delivery of oxygen, carbon dioxide, and other therapeutic gases, using polymeric microcapsules (PMCs) is an emerging strategy to deliver gas as an injectable therapeutic. The gas cargo is stored within the PMC core and its release is mediated by the physiochemical properties of the capsule shell. Although use of PMCs for the rapid delivery of gases has been well described, methods which tune the material properties of PMCs for sustained release of gas are lacking. In this work, we describe a simple method for the high-yield production of gas-in-oil-filled PMCs with tunable sizes and core gas content from preformed polymers using the sequential phase separation and self-emulsification of emulsion-based templates. We demonstrate that prolonged gas release occurs from gas-in-oil PMCs loaded with oxygen and carbon dioxide gas, each of which could have significant clinical applications.
- Subjects :
- 0301 basic medicine
Materials science
Polymers
chemistry.chemical_element
02 engineering and technology
Oxygen
Injections
03 medical and health sciences
chemistry.chemical_compound
Electrochemistry
General Materials Science
Injections methods
Spectroscopy
chemistry.chemical_classification
Extramural
Gas release
Surfaces and Interfaces
Polymer
021001 nanoscience & nanotechnology
Condensed Matter Physics
Controlled release
030104 developmental biology
chemistry
Chemical engineering
Delayed-Action Preparations
Emulsion
Carbon dioxide
Emulsions
Gases
0210 nano-technology
Subjects
Details
- ISSN :
- 15205827
- Volume :
- 34
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Accession number :
- edsair.doi.dedup.....609cdb9fd8468ee4520874b41bcc5938