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Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
- Source :
- PLoS ONE, Vol 16, Iss 10 (2021), PLoS ONE, PLoS ONE, Vol 16, Iss 10, p e0258922 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Background Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators. Objectives This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains. Methods This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.0% men; aged 71.36 ± 5.96 years). Obesity-related indicators included body mass index (BMI), waist circumference (WC), calf circumference (CC), waist to hip ratio (WHR), waist to calf circumstance ratio (WCR), fat to fat-free mass ratio (FM/FFM). The Mini-Mental State Examination scale (MMSE) was used to assess cognitive function. Cognitive impairment was defined as a score ≤ 17 for illiterates, ≤ 20 for participants with primary school education, and ≤ 24 for those with junior high school degrees or above. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to analyze and visualize the linear relationships. Results The prevalence of cognitive impairment was 18.77%. In the fully adjusted model, CC was negatively associated with cognitive impairment (OR = 0.94, 95% CI: 0.90−0.98). Further analysis showed that CC correlated positively with recall and place orientation. A higher FM/FFM was found to be associated with a higher prevalence of cognitive impairment (OR: 1.44, 95%CI: 0.88–2.35, P for trend = 0.029); this association was notable in women (P for trend = 0.002) and the oldest (P for trend = 0.009), and so did the potential effect of BMI on cognitive impairment (70–80 years: P for trend = 0.011; ≥ 80 years: P for trend = 0.013). No statistically significant association was found between cognitive impairment and WC, WHR, or WCR. Conclusion CC and FM/FFM were associated with cognitive impairment in older people. Future research needs to distinguish the effects of fat and muscle mass on cognitive function, with special attention to different ages and genders.
- Subjects :
- Male
Physiology
Body Mass Index
Waist–hip ratio
Elderly
Endocrinology
Medical Conditions
Risk Factors
Medicine and Health Sciences
Medicine
Public and Occupational Health
Cognitive Impairment
Multidisciplinary
Cognitive Neurology
Cognition
Neurology
Physiological Parameters
Adipose Tissue
Connective Tissue
Female
Anatomy
Research Article
China
Waist
Endocrine Disorders
Cognitive Neuroscience
Science
Diabetes Mellitus
Humans
Adults
Body Weights and Measures
Cognitive Dysfunction
Obesity
Aged
Nutrition
business.industry
Body Weight
Biology and Life Sciences
Odds ratio
Physical Activity
Anthropometry
medicine.disease
Confidence interval
Cross-Sectional Studies
Biological Tissue
Age Groups
Metabolic Disorders
People and Places
Cognitive Science
Population Groupings
business
Body mass index
Demography
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....6075b4d61125095b9af1fed46ce4dc8c