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Association of Drusen Volume with Choroidal Parameters in Non-Neovascular Age-Related Macular Degeneration
- Publication Year :
- 2017
-
Abstract
- Purpose The choroid is thought to be relevant to the pathogenesis of nonneovascular age-related macular degeneration, but its role has not yet been fully defined. In this study, we evaluate the relationship between the extent of macular drusen and specific choroidal parameters, including thickness and intensity. Methods Spectral domain optical coherence tomography images were collected from two distinct, independent cohorts with nonneovascular age-related macular degeneration: Amish (53 eyes of 34 subjects) and non-Amish (40 eyes from 26 subjects). All spectral domain optical coherence tomography scans were obtained using the Cirrus HD-OCT with a 512 × 128 macular cube (6 × 6 mm) protocol. The Cirrus advanced retinal pigment epithelium analysis tool was used to automatically compute drusen volume within 3 mm (DV3) and 5 mm (DV5) circles centered on the fovea. The inner and outer borders of the choroid were manually segmented, and the mean choroidal thickness and choroidal intensity (i.e., brightness) were calculated. The choroidal intensity was normalized against the vitreous and nerve fiber layer reflectivity. The correlation between DV and these choroidal parameters was assessed using Pearson and linear regression analysis. Results A significant positive correlation was observed between normalized choroidal intensity and DV5 in the Amish (r = 0.42, P = 0.002) and non-Amish (r = 0.33, P = 0.03) cohorts. Also, DV3 showed a significant positive correlation with normalized choroidal intensity in both the groups (Amish: r = 0.30, P = 0.02; non-Amish: r = 0.32, P = 0.04). Choroidal thickness was negatively correlated with normalized choroidal intensity in both Amish (r = -0.71, P = 0.001) and non-Amish (r = -0.43, P = 0.01) groups. Normalized choroidal intensity was the most significant constant predictor of DV in both the Amish and non-Amish groups. Conclusion Choroidal intensity, but not choroidal thickness, seems to be associated with drusen volume in Amish and non-Amish populations. These observations suggest that choroidal parameters beyond thickness warrant further study in the setting of age-related macular degeneration.
- Subjects :
- Male
medicine.medical_specialty
Fovea Centralis
Visual acuity
genetic structures
Nerve fiber layer
Visual Acuity
Retinal Drusen
Drusen
Severity of Illness Index
Article
03 medical and health sciences
0302 clinical medicine
Optical coherence tomography
Ophthalmology
medicine
Humans
Aged
Retinal pigment epithelium
medicine.diagnostic_test
business.industry
Choroid
digestive, oral, and skin physiology
General Medicine
Macular degeneration
Pennsylvania
medicine.disease
humanities
eye diseases
Intensity (physics)
medicine.anatomical_structure
030221 ophthalmology & optometry
Florida
Wet Macular Degeneration
Female
sense organs
medicine.symptom
Morbidity
business
Amish
030217 neurology & neurosurgery
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6065cea25262f96fbdf245552f53abb8