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A novel process for scopolamine separation from Hindu Datura extracts by liquid–liquid extraction, macroporous resins, and crystallization
- Source :
- Separation Science and Technology. 55:922-931
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- An efficient separation method of scopolamine from Hindu Datura extracts was successfully developed by combining liquid–liquid extraction, macroporous resins, and crystallization. First, the extraction solution was successively performed with liquid–liquid extraction by acid water and carbon tetrachloride. Secondly, D151 resin was selected from six tested resins, and the separation parameters were optimized. Finally, scopolamine hydrobromide was obtained after crystallization at −20°C overnight. Through one run of above combined treatments, the content of scopolamine increased from 3.02% (w/w) to 99.12% (w/w). In addition, the products were assessed by high-performance liquid chromatography (HPLC).
- Subjects :
- Chromatography
Chemistry
Process Chemistry and Technology
General Chemical Engineering
Extraction (chemistry)
Filtration and Separation
02 engineering and technology
General Chemistry
010501 environmental sciences
01 natural sciences
law.invention
020401 chemical engineering
Liquid–liquid extraction
law
Hindu datura
Scientific method
Scopolamine
medicine
Separation method
0204 chemical engineering
Crystallization
0105 earth and related environmental sciences
medicine.drug
Subjects
Details
- ISSN :
- 15205754 and 01496395
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Separation Science and Technology
- Accession number :
- edsair.doi.dedup.....6064b5cf8199ef185083dfef0ca08837