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Cortical Dopamine Transmission as Measured with the [11C]FLB 457 – Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 6, p e0157867 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1 and D2/3 receptor binding potential (BP), and interpreted them in terms of dopaminergic tone. The use of baseline dopamine D1 and D2/3 receptor binding potential (BPND) as a proxy for dopaminergic tone is problematic because they reflect both endogenous dopamine levels (a change in radiotracer's apparent affinity) and receptor density. In this analysis of 31 healthy controls genotyped for the Val158Met polymorphism (Val/Val, Val/Met, and Met/Met), we used amphetamine-induced displacement of [11C]FLB 457 as a direct measure of dopamine release. Our analysis failed to show a relationship between COMT genotype status and prefrontal cortical dopamine release. COMT genotype was also not predictive of baseline dopamine D2/3 receptor BPND.
- Subjects :
- Male
Pyrrolidines
Physiology
Dopamine
lcsh:Medicine
Biochemistry
Diagnostic Radiology
Receptors, Dopamine
0302 clinical medicine
Catecholamines
Cerebellum
Salicylamides
Medicine and Health Sciences
Amines
lcsh:Science
Prefrontal cortex
Tomography
Cerebral Cortex
Multidisciplinary
Organic Compounds
Radiology and Imaging
Dopaminergic
Drugs
Brain
Neurochemistry
Neurotransmitters
Electrophysiology
Chemistry
Behavioral Pharmacology
Anesthesia
Physical Sciences
Female
Anatomy
Neurochemicals
rs4680
medicine.drug
Research Article
Adult
medicine.medical_specialty
Biogenic Amines
Genotype
Imaging Techniques
Receptor potential
Prefrontal Cortex
Neuroimaging
Biology
Research and Analysis Methods
Catechol O-Methyltransferase
Membrane Potential
03 medical and health sciences
Diagnostic Medicine
Receptor Potentials
Internal medicine
Dopamine receptor D2
Recreational Drug Use
medicine
Humans
Amphetamine
Demography
Pharmacology
Catechol-O-methyl transferase
lcsh:R
Organic Chemistry
Amphetamines
Chemical Compounds
Biology and Life Sciences
Hormones
030227 psychiatry
Endocrinology
Positron-Emission Tomography
People and Places
lcsh:Q
Dopaminergics
030217 neurology & neurosurgery
Positron Emission Tomography
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....60618fd943b0e03d927d50187641bd96