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Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol
- Source :
- BJGP Open (2020), BJGP Open
- Publication Year :
- 2021
- Publisher :
- Royal College of General Practitioners, 2021.
-
Abstract
- BackgroundClinical guidelines recommend specific targets for low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) for primary prevention of cardiovascular disease (CVD). Furthermore, individual variability in lipid response to statin therapy requires assessment of the association in diverse populations.AimTo assess whether lower concentrations of LDL-C and non-HDL-C are associated with a reduced risk of major adverse cardiovascular events (MACE) in primary prevention of CVD.Design & settingAn international, new-user, cohort study will be undertaken. It will use data from three electronic health record databases from three global regions: Clinical Practice Research Datalink, UK; PREDICT-CVD, New Zealand (NZ); and the Clinical Data and Analysis Reporting System, Hong Kong (HK).MethodNew statin users without a history of atherosclerotic CVD, heart failure, or chronic kidney disease, with baseline and follow-up lipid levels will be eligible for inclusion. Patients will be classified according to LDL-C (ConclusionResults will inform clinicians about the benefits of achieving guideline recommended concentrations of LDL-C for primary prevention of CVD.
- Subjects :
- medicine.medical_specialty
Statin
medicine.drug_class
hydroxymethylglutaryl-coa reductase inhibitors
primary prevention
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
cohort studies
Internal medicine
Medicine
030212 general & internal medicine
cardiovascular diseases
lcsh:R5-920
business.industry
Cholesterol
Research
cholesterol
Guideline
medicine.disease
major adverse cardiovascular events
chemistry
Heart failure
lipids (amino acids, peptides, and proteins)
lcsh:Medicine (General)
Family Practice
business
Mace
Cohort study
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 23983795
- Database :
- OpenAIRE
- Journal :
- BJGP Open (2020), BJGP Open
- Accession number :
- edsair.doi.dedup.....60608e6bb7b06d57871926c205ab0951