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Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling
- Source :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Year :
- 2021
- Publisher :
- Proceedings of the National Academy of Sciences, 2021.
-
Abstract
- We appreciate the constructive comments by Cheng et al. (1), who performed an intensive statistical analysis of cytokine levels in patients with COVID-19. Their work applies the inverse-variance weighted (IVW) method and an MR-Egger regression on a large number of patients for a statistical analysis to identify COVID-19 risk factors. Consistent with our previous work (2), the results of these analyses suggest that the plasma from patients with COVID-19 has significantly lower levels of interleukin (IL)-8, IL-10, and monocyte chemoattractant protein (MCP)-1, compared with that from patients with other types of cytokine release syndrome (CRS). Previously, we proposed that the elevation of four proinflammatory cytokines, that is, IL-6, … [↵][1]1To whom correspondence may be addressed. Email: kishimoto{at}ifrec.osaka-u.ac.jp. [1]: #xref-corresp-1-1
- Subjects :
- Letter
Endothelium
medicine.medical_treatment
030204 cardiovascular system & hematology
Proinflammatory cytokine
03 medical and health sciences
Immunology and Inflammation
0302 clinical medicine
Humans
Medicine
030212 general & internal medicine
Interleukin 8
Interleukin 6
Chemokine CCL2
Multidisciplinary
biology
Interleukin-6
SARS-CoV-2
business.industry
Interleukin-8
COVID-19
Endothelial Cells
Interleukin
Biological Sciences
medicine.disease
Interleukin-10
Interleukin 10
Cytokine release syndrome
medicine.anatomical_structure
Cytokine
Immunology
biology.protein
Cytokine Release Syndrome
business
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....604a67f2dde84e26cd526441d146fe53