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Examining the association between adiposity and DNA methylation: A systematic review and meta‐analysis
- Source :
- Obesity Reviews. 22
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Obesity is associated with widespread differential DNA methylation (DNAm) patterns, though there have been limited overlap in the obesity-associated cytosine-guanine nucleotide pair (CpG) sites that have been identified in the literature. We systematically searched four databases for studies published until January 2020. Eligible studies included cross-sectional, longitudinal, or intervention studies examining adiposity and genome-wide DNAm in non-pregnant adults aged 18-75 in all tissue types. Study design and results were extracted in the descriptive review. Blood-based DNAm results in body mass index (BMI) and waist circumference (WC) were meta-analyzed using weighted sum of Z-score meta-analysis. Of the 10,548 studies identified, 46 studies were included in the systematic review with 18 and nine studies included in the meta-analysis of BMI and WC, respectively. In the blood, 77 and four CpG sites were significant in three or more studies of BMI and WC, respectively. Using a genome-wide threshold for significance, 52 blood-based CpG sites were significantly associated with BMI. These sites have previously been associated with many obesity-related diseases including type 2 diabetes, cardiovascular disease, Crohn's disease, and depression. Our study shows that DNAm at 52 CpG sites represent potential mediators of obesity-associated chronic diseases and may be novel intervention or therapeutic targets to protect against obesity-associated chronic diseases.
- Subjects :
- Adult
Oncology
medicine.medical_specialty
Waist
Endocrinology, Diabetes and Metabolism
Disease
Type 2 diabetes
Body Mass Index
Internal medicine
medicine
Humans
Obesity
Adiposity
business.industry
Public Health, Environmental and Occupational Health
dNaM
DNA Methylation
medicine.disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
CpG site
Meta-analysis
DNA methylation
Waist Circumference
business
Body mass index
Subjects
Details
- ISSN :
- 1467789X and 14677881
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Obesity Reviews
- Accession number :
- edsair.doi.dedup.....602ca0e40314c9720481581c170fc5a8