Back to Search
Start Over
Kinetically Controlled Chemoselective Cyclization Simplifies the Access to Cyclic and Branched Peptides
- Source :
- Organic Letters, Organic Letters, American Chemical Society, 2016, 18 (15), pp.3842-3845. ⟨10.1021/acs.orglett.6b01847⟩
- Publication Year :
- 2016
-
Abstract
- A bis(2-sulfanylethyl)amido group reacts significantly faster with cysteinyl peptides when installed on the C-terminal end of a peptide in comparison with the side-chain of Asp and Glu. This property enabled the design of a kinetically controlled chemoselective peptide cyclization reaction, giving straightforward access to cyclic and branched peptides in one pot.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Stereochemistry
Chemistry
Organic Chemistry
Peptide
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
0104 chemical sciences
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Group (periodic table)
[CHIM]Chemical Sciences
Physical and Theoretical Chemistry
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 18
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....60284050646d704ddf0bc0a0a9f9ce78