Back to Search
Start Over
Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device
- Source :
- American journal of ophthalmology. 155(3)
- Publication Year :
- 2012
-
Abstract
- To evaluate the effects of a novel ab interno trabeculectomy device on human trabecular meshwork (TM).Laboratory evaluation.The TM from human cadaveric corneal rim tissue was incised using 3 instruments: (1) novel dual-blade device; (2) microvitreoretinal (MVR) blade; and (3) Trabectome. Tissue samples underwent histologic processing and comparative analyses. Subsequently, human eye perfusion studies were performed to evaluate intraocular pressure (IOP)-lowering effects of each device. Main outcome measures were degree of TM removal by histology and IOP in a perfusion model.The MVR blade exhibited minimal removal of TM and obvious injury to the adjacent sclera. The Trabectome removed a large portion of the central TM, but leaflets of residual tissue remained and thermal injury was noted in all samples. The dual-blade device achieved a more complete removal of TM without injury to surrounding tissues. All devices resulted in statistically significant lowering of IOP during perfusion model studies. MVR blade treatment across 170.0 ± 14.1 degrees of TM resulted in a decrease of IOP from 18.5 ± 1.9 mm Hg to 12.8 ± 2.2 mm Hg (P.01). Trabectome treatment across 117.5 ± 12.6 degrees resulted in a decrease of IOP from 18.8 ± 1.7 mm Hg to 11.3 ± 1.0 mm Hg (P.01). Dual-blade device treatment across 157.5 ± 26.3 degrees resulted in a decrease of IOP from 18.3 ± 3.0 mm Hg to 11.0 ± 2.2 mm Hg (P.01).The novel dual-blade device demonstrated a more complete removal of TM without residual TM leaflets or damage to surrounding tissues and significantly reduced IOP in a human eye perfusion model.
- Subjects :
- medicine.medical_specialty
Intraocular pressure
genetic structures
business.industry
medicine.medical_treatment
Histology
Trabeculectomy
eye diseases
Tissue Donors
Surgery
Sclera
Ophthalmology
medicine.anatomical_structure
Trabecular Meshwork
medicine
Trabectome
Humans
sense organs
Trabecular meshwork
Cadaveric spasm
business
Perfusion
Intraocular Pressure
Subjects
Details
- ISSN :
- 18791891
- Volume :
- 155
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of ophthalmology
- Accession number :
- edsair.doi.dedup.....6011523165a4d6ece83b1bd003b0c66a