EPIDEMIOLOGY AND BIOMOLECULAR CHARACTERIZATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE IN AN ITALIAN HOSPITAL

OBJECTIVE. To describe the occurrence of CRKP infections in a tertiary care hospital and to analyse the allelic profiles of the clinical strains involved and the most frequent carbapenemases. DESIGN. The study analyzed cases of infection due to CRKP in the period 2013-2014. 147 cases of CRKP infection were recorded most of which (82.31%) were in-hospital infections. SETTING. One hospital in northern Italy. METHODS. We retrospectively collected: data on patient characteristics, microbiological characteristics of CRKP. The isolates from 72 of the-hospital cases underwent molecular typing (MLST); in addition, in each isolate, a procedure for the detection of the blaKPC gene was carried out. RESULTS: The in-hospital death rate was 24.0% in 2013 and 37.5% in 2014. However, the difference between these two values did not prove statistically significant (P> .05). Analysis of mortality revealed that bloodstream infections were more frequently associated with death than other infections (CHI2=14.57, P
Journal of Preventive Medicine and Hygiene, Vol 57, No 3 (2016): 2016573