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Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold
- Source :
- Biomaterials, Biomaterials, Elsevier, 2009, 30 (25), pp.4219-4226. ⟨10.1016/j.biomaterials.2009.04.026⟩
- Publication Year :
- 2009
-
Abstract
- International audience; A computational model based on finite element method (FEM) and computational fluid dynamics (CFD) is developed to analyse the mechanical stimuli in a composite scaffold made of polylactic acid (PLA) matrix with calcium phosphate glass (Glass) particles. Different bioreactor loading conditions were simulated within the scaffold. In vitro perfusion conditions were reproduced in the model. Dynamic compression was also reproduced in an uncoupled fluid-structure scheme: deformation level was studied analyzing the mechanical response of scaffold alone under static compression while strain rate was studied considering the fluid flow induced by compression through fixed scaffold. Results of the model show that during perfusion test an inlet velocity of 25 mm/s generates on scaffold surface a fluid flow shear stress which may stimulate osteogenesis. Dynamic compression of 5% applied on the PLA– Glass scaffold with a strain rate of 0.005 s À1 has the benefit to generate mechanical stimuli based on both solid shear strain and fluid flow shear stress on large scaffold surface area. Values of perfusion inlet velocity or compression strain rate one order of magnitude lower may promote cell proliferation while values one order of magnitude higher may be detrimental for cells. FEM–CFD scaffold models may help to determine loading conditions promoting bone formation and to interpret experimental results from a mechanical point of view.
- Subjects :
- Calcium Phosphates
Scaffold
Materials science
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Compressive Strength
Polymers
Polyesters
0206 medical engineering
Microfluidics
Biophysics
Mechanical stimuli
Bioengineering
Biocompatible Materials
02 engineering and technology
Computational fluid dynamics
Mechanotransduction, Cellular
Bone tissue engineering
Biomaterials
03 medical and health sciences
Osteogenesis
Materials Testing
Shear stress
Fluid dynamics
Shear strength
Computer Simulation
Lactic Acid
Composite material
030304 developmental biology
0303 health sciences
Tissue Engineering
Tissue Scaffolds
Finite element analysis
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Strain rate
Compression (physics)
020601 biomedical engineering
[SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of the structures [physics.class-ph]
Compressive strength
Mechanics of Materials
Ceramics and Composites
Glass
Stress, Mechanical
Deformation (engineering)
Shear Strength
Subjects
Details
- ISSN :
- 18785905 and 01429612
- Volume :
- 30
- Issue :
- 25
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....6001b4c13789e3c0e26dcf7af26b90c5