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Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities
- Source :
- Chinese journal of natural medicines. 20(3)
- Publication Year :
- 2021
-
Abstract
- Two cardenolide glycosides, corotoxigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] ( 1 ) and coroglaucigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] ( 2 ), were isolated from the seed fairs of Asclepias curassavica L.. The structures of 1 − 2 were determined based on a combination of the analysis of their MS, NMR spectroscopic data and acid hydrolysis. The inhibitory effects of compounds 1 and 2 on human colorectal carcinoma cells (HCT116), non-small cell lung carcinoma cells (A549) and hepatic cancer cells (SMMC-7721) were evaluated. The results showed that both compounds 1 and 2 could significantly inhibit the viability, proliferation, and migration of A549, HCT116 and SMMC-7721 cells, suggesting that compounds 1 and 2 could be applied in the treatment of lung, colon and liver cancers in clinical practice. This study may not only provide a scientific basis for clarifying the active ingredients in A. curassavica L., but also help to understand its antitumor activity, which could promote the application of A. curassavica L. in clinical treatment of various cancers.
- Subjects :
- Asclepias curassavica
Colorectal cancer
Cell
Antineoplastic Agents
Pharmacology
chemistry.chemical_compound
Drug Discovery
medicine
Cardenolide
Carcinoma
Cytotoxic T cell
Humans
Glycosides
Asclepias
chemistry.chemical_classification
biology
Chemistry
Glycoside
General Medicine
medicine.disease
biology.organism_classification
Cardenolides
medicine.anatomical_structure
Complementary and alternative medicine
Cancer cell
Seeds
Subjects
Details
- ISSN :
- 18755364
- Volume :
- 20
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Chinese journal of natural medicines
- Accession number :
- edsair.doi.dedup.....5ff0a658b8768de9e4d7108f48162837