Expression of miR-148/152 Family as Potential Biomarkers in Non-Small-Cell Lung Cancer

Background Altered miR-148/152 family expression contributes to human carcinogenesis. This study was designed to detect the potential for using miR-148/152 family as biomarkers for NSCLC patients. Material/Methods The relative expression levels of miR-148/152 family (miR-148a, miR-148b, and miR-152) in serum of 36 non-small-cell lung carcinoma (NSCLC) patients, 20 patients with benign pulmonary diseases (BPD), and 10 healthy individuals were assessed by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR). Results The expression of all three miRNAs were significantly lower in the serum of NSCLC than that of BPD and healthy controls (all p