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Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients
- Source :
- Journal of virology. 82(18)
- Publication Year :
- 2008
-
Abstract
- Among 17 HLA-A2-positive healthy adults, CD8+T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+T-cell responses in some vaccinees.
- Subjects :
- CD4-Positive T-Lymphocytes
Cellular immunity
Influenza vaccine
Immunology
Orthomyxoviridae
Epitopes, T-Lymphocyte
CD8-Positive T-Lymphocytes
medicine.disease_cause
Microbiology
Virus
Epitope
Cell Line
Viral Matrix Proteins
Influenza A Virus, H1N1 Subtype
Virology
HLA-A2 Antigen
Influenza, Human
Influenza A virus
medicine
Cytotoxic T cell
Humans
biology
Influenza A Virus, H3N2 Subtype
biology.organism_classification
Vaccines, Inactivated
Influenza Vaccines
Insect Science
Inactivated vaccine
Pathogenesis and Immunity
Subjects
Details
- ISSN :
- 10985514
- Volume :
- 82
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of virology
- Accession number :
- edsair.doi.dedup.....5fe961bd039339931bb870f1276d4580