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Proteomic investigation of human cystic echinococcosis in the liver
- Source :
- Molecular and Biochemical Parasitology. 211:9-14
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Cystic echinococcosis (CE) is a pandemic infectious disease caused by the tapeworm Echinococcus granulosus that forms cysts in different organs such as lungs and liver. Imaging examination and serological tests have some drawbacks such as low sensitivity. In this study, we used an up-to-date workflow of laser microdissection-based microproteomics and matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry in order to depict the proteomic pattern of CE in the liver. This investigation revealed specific markers of a parasitic cyst in liver. This proteomic pattern could facilitate diagnosis of CE in the future.
- Subjects :
- Proteomics
0301 basic medicine
Echinococcosis, Hepatic
Pathology
medicine.medical_specialty
Proteome
Laser Capture Microdissection
Mass spectrometry imaging
03 medical and health sciences
0302 clinical medicine
Tandem Mass Spectrometry
parasitic diseases
medicine
Animals
Humans
Echinococcus granulosus
Molecular Biology
Laser capture microdissection
biology
Cystic echinococcosis
Parasitic cyst
biology.organism_classification
medicine.disease
030104 developmental biology
Infectious disease (medical specialty)
030220 oncology & carcinogenesis
Parasitic disease
Immunology
Parasitology
Chromatography, Liquid
Subjects
Details
- ISSN :
- 01666851
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- Molecular and Biochemical Parasitology
- Accession number :
- edsair.doi.dedup.....5fe346dcf4f237abdd5c81e27f16cbf4