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Imidazoline Receptors Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage
- Source :
- Current Molecular Medicine. 18
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- Intracerebral hemorrhage (ICH), which accounts for 10% of all strokes, leads to higher morbidity and mortality compared with other stroke subtypes. Hypertension has been recognized as a major risk factor for ICH. Current antihypertensive options have not been fully effective for either prevention of ICH or ameliorating its complications. Therefore, attempts should be made to use novel antihypertensive medications for more effective management of blood pressure (BP) in the acute phase of ICH. Imidazoline receptor (IR) agonists can potentially be effective agents for BP control with the adjunctive ability to attenuate post-ICH brain injury. IR agonists render neuroprotective effects including inhibition of inflammatory reactions, apoptotic cell death, excitotoxicity, and brain edema. Given these properties, the present review aims to focus on the application of IR agonists for managing BP in ICH patients.
- Subjects :
- Excitotoxicity
Imidazoline receptor
Blood Pressure
Inflammation
030204 cardiovascular system & hematology
Pharmacology
medicine.disease_cause
Biochemistry
Neuroprotection
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Medicine
cardiovascular diseases
Risk factor
Molecular Biology
Stroke
Antihypertensive Agents
Cerebral Hemorrhage
Intracerebral hemorrhage
business.industry
General Medicine
medicine.disease
nervous system diseases
Blood pressure
Hypertension
Molecular Medicine
Imidazoline Receptors
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15665240
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Molecular Medicine
- Accession number :
- edsair.doi.dedup.....5fc5efbdb1634b4b5c0d4afd0e3083d6