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Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
- Publication Year :
- 2010
- Publisher :
- Korean Society for Biochemistry and Molecular Biology, 2010.
-
Abstract
- Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P < 0.05) and SNP analyses (FDR < 0.05). VCAM1 rs3176867, ALOX5 rs7099684, and MPO rs2071409 were the three most significant SNPs. They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in ALOXE3 (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P = 0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary.
- Subjects :
- Adult
Male
medicine.medical_specialty
Clinical Biochemistry
Vascular Cell Adhesion Molecule-1
Single-nucleotide polymorphism
Cell Count
Biology
Biochemistry
Polymorphism, Single Nucleotide
Immune system
Immunity
White blood cell
Internal medicine
Occupational Exposure
medicine
Leukocytes
SNP
Humans
Genetic Predisposition to Disease
Molecular Biology
Gene
Genetic Association Studies
Peroxidase
Genetics
Hematology
Innate immune system
Arachidonate 5-Lipoxygenase
Benzene
Hematologic Diseases
Immunity, Innate
medicine.anatomical_structure
Cross-Sectional Studies
Immunology
Molecular Medicine
Original Article
Female
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5fc3c67f59e86f8bbdd615f97886e521