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Clinical Significance of NADPH Oxidase 5 in Human Colon Cancer
- Source :
- Anticancer Research. 39:4405-4410
- Publication Year :
- 2019
- Publisher :
- Anticancer Research USA Inc., 2019.
-
Abstract
- Background/aim Recent studies have reported the involvement of NADPH oxidases (NOXs) in tumor progression. However, the role of NOX5 in colon cancer is unclear. We examined the clinical significance of NOX5 expression in colon cancer. Patients and methods NOX5 expression was evaluated by immunohistochemistry in 119 patients with stage II or III colon cancer, and the relationship between NOX5 expression and clinicopathological data was analyzed. Results Of all tissues, 39.5% were negative and 60.5% were positive for NOX5 expression. Positive expression was significantly associated with undifferentiated histology (p=0.037) and lymph node metastasis (p=0.023). The 5-year progression-free survival rate of NOX5-positive patients was significantly worse than that of NOX5-negative patients (p=0.046). The rates of local recurrence observed in NOX5-positive patients were higher than that in NOX5-negative patients. Conclusion NOX5 expression may be related to poor prognostic factors and could be useful as a prognostic biomarker.
- Subjects :
- Male
Cancer Research
Colorectal cancer
03 medical and health sciences
0302 clinical medicine
Biomarkers, Tumor
medicine
Humans
Clinical significance
Survival rate
Aged
Neoplasm Staging
business.industry
Histology
General Medicine
Prognosis
medicine.disease
Progression-Free Survival
Gene Expression Regulation, Neoplastic
Human colon cancer
NADPH Oxidase 5
Oncology
Tumor progression
030220 oncology & carcinogenesis
Colonic Neoplasms
NADPH oxidase 5
Cancer research
Immunohistochemistry
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....5fc3c385cbd94fffeffe12d533aa56db