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Systems biology network reveals the correlation between COX-2 expression and Ch 7q copy number alterations in Ch 11q-deleted pediatric neuroblastoma tumors
- Source :
- Genes & Cancer. 13:60-71
- Publication Year :
- 2022
- Publisher :
- Impact Journals, LLC, 2022.
-
Abstract
- Tumor-associated inflammation and chromosomal aberrations can play crucial roles in cancer development and progression. In neuroblastoma (NB), the enzyme cyclooxygenase-2 (COX-2) is associated with copy number alterations on the long arm of chromosome 11 (Ch 11q), defining an aggressive disease subset. This retrospective study included formalin-fixed paraffin-embedded tumor samples collected from nine patients during diagnosis at the pediatric Pequeno Principe Hospital, Curitiba, PR, Brazil, and post-chemotherapy (CT). COX-2 expression was evaluated using immunohistochemistry and correlated with the genome profile of paired pre- and post-CT samples, determined by array comparative genomic hybridization. A systems biology approach elucidated the
- Subjects :
- Cancer Research
Genetics
Subjects
Details
- ISSN :
- 19476027
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Genes & Cancer
- Accession number :
- edsair.doi.dedup.....5fc097f82d95e22651453e3532ff283e