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Localization of the hand motor area by arterial spin labeling and blood oxygen level-dependent functional magnetic resonance imaging
- Source :
- Hum Brain Mapp
- Publication Year :
- 2010
-
Abstract
- The new clinically available arterial spin labeling (ASL) perfusion imaging sequences present some advantages relatively to the commonly used blood oxygen level‐dependent (BOLD) method for functional brain studies using magnetic resonance imaging (MRI). In particular, regional cerebral blood flow (CBF) changes are thought to be more directly related with neuronal activation. In this study, we aimed to investigate the accuracy of the functional localization of the hand motor area obtained by simultaneous CBF and BOLD contrasts provided by ASL functional MRI (fMRI) and compare it with a standard BOLD fMRI protocol. For this purpose, we measured the distance between the center of gravity of the activation clusters obtained with each contrast (CBF, BOLD(ASL), and Standard BOLD) and 11 positions defined on a well‐established anatomical landmark of the hand motor area (the omega in the axial plane of the precentral gyrus). We found that CBF measurements were significantly closer to the anatomical landmark than the ones obtained using either simultaneous BOLD(ASL) or standard BOLD contrasts. Moreover, we also observed reduced intersubject variability of the functional localization, as well as percent signal change, for CBF relative to both BOLD contrast measurements. In conclusion, our results add further evidence in support to the notion that CBF provides a more accurate localization of motor activation than BOLD contrast, indicating that ASL may be an appropriate technique for clinical fMRI studies. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
- Subjects :
- Adult
Male
genetic structures
Perfusion scanning
behavioral disciplines and activities
Functional Laterality
Young Adult
Nuclear magnetic resonance
medicine
Humans
Radiology, Nuclear Medicine and imaging
Research Articles
Observer Variation
Brain Mapping
Blood-oxygen-level dependent
Motor area
Radiological and Ultrasound Technology
medicine.diagnostic_test
Motor Cortex
Precentral gyrus
Reproducibility of Results
Magnetic resonance imaging
Cerebral Arteries
Middle Aged
Hand
Magnetic Resonance Imaging
Oxygen
Neurology
Cerebral blood flow
nervous system
Arterial spin labeling
Female
Neurology (clinical)
Anatomy
Anatomic Landmarks
Functional magnetic resonance imaging
Psychology
Neuroscience
psychological phenomena and processes
Subjects
Details
- ISSN :
- 10970193
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Human brain mapping
- Accession number :
- edsair.doi.dedup.....5fbe5b52c0e1033f7723c1040e682bfd