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Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture
- Source :
- Neuroscience letters. 119(2)
- Publication Year :
- 1990
-
Abstract
- In a previous paper it has been reported that the repetitive conjunctive stimulation of both a granule cell and an inferior-olivary neuron depresses the synaptic transmission between a cerebellar granule cell and a Purkinje cell, and the repetitive stimulation of only a granule cell potentiates the transmission in a simple culture preparation. This paper demonstrates, by experiments controlling the membrane potential of a postsynaptic Purkinje cell, that the postsynaptic depolarization of a Purkinje cell during activation of a granule cell is both necessary and sufficient to induce the depression, and that the potentiation is induced without the postsynaptic depolarization.
- Subjects :
- Neurons
Neuronal Plasticity
Post-tetanic potentiation
General Neuroscience
Purkinje cell
Action Potentials
Depolarization
Biology
Olivary Nucleus
Inhibitory postsynaptic potential
Granule cell
Rats
Electrophysiology
Purkinje Cells
medicine.anatomical_structure
Postsynaptic potential
Cerebellum
Synapses
medicine
Excitatory postsynaptic potential
Animals
Neuroscience
Postsynaptic density
Cells, Cultured
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 119
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....5fb1a7ff78fec8e5cd96d8604607def3