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Neurological manifestations of polyarteritis nodosa: a tour of the neuroaxis by case series
- Source :
- BMC neurology, vol 21, iss 1, BMC Neurology, BMC Neurology, Vol 21, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Background Heterogenous central nervous system (CNS) neurologic manifestations of polyarteritis nodosa (PAN) are underrecognized. We review three cases of patients with PAN that illustrate a range of nervous system pathology, including the classical mononeuritis multiplex as well as uncommon brain and spinal cord vascular manifestations. Case presentation Case 1 presented with mononeuritis multiplex and characteristic skin findings. Case 2 presented with thunderclap headache and myelopathy due to spinal artery aneurysm rupture. Both patients experienced disease remission upon treatment. Case 3 presented with headache and bulbar symptoms due to partially thrombosed intracranial aneurysms, followed by systemic manifestations related to visceral aneurysms. She demonstrated clinical improvement with treatment, was lost to follow-up, then clinically deteriorated and entered hospice care. Conclusions Although the peripheral manifestations of PAN are well-known, PAN association with CNS neurovascular disease is relatively underappreciated. Clinician awareness of the spectrum of neurologic disease is required to reduce diagnostic delay and promote prompt diagnosis and treatment with immunosuppressants.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
Delayed Diagnosis
Case Report
Aneurysm, Ruptured
Myelopathy
Rare Diseases
medicine
Humans
RC346-429
Case series
Spinal artery aneurysm
Thunderclap headaches
Multidisciplinary
Neurology & Neurosurgery
Mononeuritis Multiplex
Polyarteritis nodosa
business.industry
Headache
Neurosciences
Intracranial Aneurysm
General Medicine
Middle Aged
medicine.disease
Spinal cord
Dermatology
Spinal Artery
Aneurysm
Ruptured
Brain Disorders
medicine.anatomical_structure
Good Health and Well Being
Neurological
Female
Cognitive Sciences
Neurology. Diseases of the nervous system
Neurology (clinical)
Neurosurgery
Nervous System Diseases
business
Immunosuppressive Agents
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC neurology, vol 21, iss 1, BMC Neurology, BMC Neurology, Vol 21, Iss 1, Pp 1-8 (2021)
- Accession number :
- edsair.doi.dedup.....5fb0dea627a15bf060e41929ba3ad823