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Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice
- Source :
- International Immunopharmacology. 48:135-145
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Diallyl trisulfide (DATS), a natural agent derived from garlic, has been tested for its antigastric cancer activities in various preliminary studies. However, more systematic pharmacodymatic (PD) and mechanistic evaluations are clearly needed. The aim of this study was to investigate the antitumor effects of DATS in the treatment of human gastric cancer cell SGC-7901 both in vitro and in vivo using widely recommended study procedures. DATS suppressed cancer cells proliferation and induced cell cycle arrest accompanied by an increase in the expressions of cyclin A2 and cyclin B1 in SGC-7901 cancer cells. DATS also caused an increase in apoptotic cell death, which involved in accumulations of bax, p53, and cytochrome C and reduction of Bcl-2 expressions. Besides, activation of JNK, ERK and p38 phosphorylation in DATS-treated cells suggested that mitogen-activated protein kinase (MAPKs) pathways were involved in DATS-induced apoptosis. Meanwhile, DATS significantly inhibited tumor growth and promoted tumor apoptosis in a xenograft model of gastric cancer cell SGC-7901. DATS inhibited tumor migration and invasion by modulating MMP9 and E-cadherin protein expressions. In addition, DATS treatment evidently increased the cytokine secretions of IL-12, TNF-α and IFN-γ (p
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
p38 mitogen-activated protein kinases
Immunology
Mice, Nude
Antineoplastic Agents
Apoptosis
Sulfides
Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
Stomach Neoplasms
Cell Line, Tumor
parasitic diseases
medicine
Animals
Humans
Immunology and Allergy
Garlic
Cyclin B1
Pharmacology
Mice, Inbred BALB C
Cell Cycle
food and beverages
Cancer
medicine.disease
Tumor Burden
Allyl Compounds
030104 developmental biology
Diallyl trisulfide
chemistry
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Cytokines
Female
Cyclin A2
Subjects
Details
- ISSN :
- 15675769
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- International Immunopharmacology
- Accession number :
- edsair.doi.dedup.....5f961a9c29b31e51addd61feb1e092da