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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity
- Source :
- Bioorganicmedicinal chemistry letters. 12(20)
- Publication Year :
- 2002
-
Abstract
- Incorporation of acidic functional groups into a lead CCR5 antagonist identified from a targeted combinatorial library resulted in compounds with enhanced anti-HIV-1 activity and attenuated L-type calcium channel affinity.
- Subjects :
- Anti hiv 1
Calcium Channels, L-Type
Chemical Phenomena
Receptors, CCR5
Stereochemistry
Anti-HIV Agents
Clinical Biochemistry
Pharmaceutical Science
CCR5 receptor antagonist
CHO Cells
Biochemistry
Chemical synthesis
Pyrrolidine
chemistry.chemical_compound
Structure-Activity Relationship
Cricetinae
Drug Discovery
Animals
Humans
Chemokine CCL4
Molecular Biology
Chemistry
Chemistry, Physical
Calcium channel
Organic Chemistry
Antagonist
virus diseases
Macrophage Inflammatory Proteins
In vitro
Rats
CCR5 Receptor Antagonists
HIV-1
Molecular Medicine
Selectivity
Half-Life
HeLa Cells
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....5f928e9e1cf95f0b91d3b0f757df4863