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Cord blood genomic analysis highlights the role of redox balance
- Source :
- Free Radical Biology and Medicine. 49:992-996
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Neonates are exposed to elevated levels of reactive oxygen species as they transition from a hypoxic intrauterine to a normoxic extrauterine environment at birth. This increased oxidative stress is associated with neonatal morbidity. Current antioxidant supplementation treatment strategies have yet to translate into improved neonatal outcomes. Our understanding of a newborn's intricate redox balance, particularly at the genomic level, remains limited. Here, we performed genomic microarray analyses (approximately 14,500 genes) on extracted mRNA from umbilical cord whole blood at term gestation (n=10). Bioinformatic analyses identified 282 genes (2.0%) that were consistently present within the highest quintile of expressed genes. These genes were highly associated with oxidant stress and included superoxide dismutase 1, catalase, peroxiredoxins, and uncoupling proteins. Pathway analyses identified statistically significantly overrepresented functional pathways including "oxidative stress," "oxidative stress response mediated by nuclear factor-erythroid 2-related factor," "hypoxia-inducible factor signaling," and "mitochondrial dysfunction" (p
- Subjects :
- Male
GPX1
Microarray
medicine.disease_cause
Biochemistry
Article
Andrology
Superoxide dismutase
Superoxide Dismutase-1
NF-E2 Transcription Factor
Physiology (medical)
medicine
Humans
Cells, Cultured
Whole blood
chemistry.chemical_classification
Reactive oxygen species
Genome
biology
Superoxide Dismutase
Microarray analysis techniques
Infant, Newborn
Peroxiredoxins
Catalase
Fetal Blood
Microarray Analysis
Oxidative Stress
chemistry
Cord blood
Immunology
biology.protein
Female
Oxidation-Reduction
Oxidative stress
Signal Transduction
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....5f8ab5c4d8720e0d5fc26feefe68cc6a