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Partial synthesis and biological evaluation of bisbenzylisoquinoline alkaloids derivatives: potential modulators of multidrug resistance in cancer
- Source :
- Journal of Asian natural products research. 14(6)
- Publication Year :
- 2012
-
Abstract
- A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in MDR cells (Bel7402 and HCT8), and most exhibited more potent MDR-reversing activity relative to the reference compound verapamil. Compounds 8, 10, 13, and 14 enhanced intracellular accumulation of doxorubicin in Bel7402 and HCT8 cells.
- Subjects :
- Pharmaceutical Science
ATP-binding cassette transporter
Pharmacology
Rhodamine 123
Benzylisoquinolines
Analytical Chemistry
chemistry.chemical_compound
Alkaloids
Drug Discovery
medicine
Humans
Doxorubicin
ATP Binding Cassette Transporter, Subfamily B, Member 1
P-glycoprotein
biology
Molecular Structure
Organic Chemistry
General Medicine
Drug Resistance, Multiple
Multiple drug resistance
Tetrandrine
Complementary and alternative medicine
chemistry
Cancer cell
biology.protein
Molecular Medicine
Intracellular
medicine.drug
Subjects
Details
- ISSN :
- 14772213
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.doi.dedup.....5f7f412d5e00b5d97043827be4788970