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Effects of Plasma Treatment on the Bioactivity of Alkali-Treated Ceria-Stabilised Zirconia/Alumina Nanocomposite (NANOZR)
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 20, International Journal of Molecular Sciences, Vol 21, Iss 7476, p 7476 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Zirconia ceramics such as ceria-stabilized zirconia/alumina nanocomposites (nano-ZR) are applied as implant materials due to their excellent mechanical properties. However, surface treatment is required to obtain sufficient biocompatibility. In the present study, we explored the material surface functionalization and assessed the initial adhesion of rat bone marrow mesenchymal stem cells, their osteogenic differentiation, and production of hard tissue, on plasma-treated alkali-modified nano-ZR. Superhydrophilicity was observed on the plasma-treated surface of alkali-treated nano-ZR along with hydroxide formation and reduced surface carbon. A decreased contact angle was also observed as nano-ZR attained an appropriate wettability index. Treated samples showed higher in vitro bovine serum albumin (BSA) adsorption, initial adhesion of bone marrow and endothelial vascular cells, high alkaline phosphatase activity, and increased expression of bone differentiation-related factors. Furthermore, the in vivo performance of treated nano-ZR was evaluated by implantation in the femur of male Sprague&ndash<br />Dawley rats. The results showed that the amount of bone formed after the plasma treatment of alkali-modified nano-ZR was higher than that of untreated nano-ZR. Thus, induction of superhydrophilicity in nano-ZR via atmospheric pressure plasma treatment affects bone marrow and vascular cell adhesion and promotes bone formation without altering other surface properties.
- Subjects :
- implant
02 engineering and technology
Alkalies
bone
Nanocomposites
Contact angle
lcsh:Chemistry
Plasma
0302 clinical medicine
Osteogenesis
Superhydrophilicity
Aluminum Oxide
lcsh:QH301-705.5
Spectroscopy
Chemistry
Cell Differentiation
General Medicine
Adhesion
021001 nanoscience & nanotechnology
Immunohistochemistry
Computer Science Applications
medicine.anatomical_structure
plasma treatment
0210 nano-technology
Biocompatibility
Zirconia alumina
Neovascularization, Physiologic
Bone and Bones
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Albumins
medicine
Humans
Physical and Theoretical Chemistry
superhydrophilicity
Cell adhesion
Molecular Biology
Spectrum Analysis
Organic Chemistry
technology, industry, and agriculture
030206 dentistry
Ce-stabilised zirconia/alumina nanocomposite
lcsh:Biology (General)
lcsh:QD1-999
surface roughness
Surface modification
Zirconium
Bone marrow
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....5f4b30ae40daaa804a718abd51a1e5d4
- Full Text :
- https://doi.org/10.3390/ijms21207476