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Somatostatin-Like Immunoreactivity in the Cerebrospinal Fluid of Aged Patients with Parkinson's Disease
- Source :
- Journal of the American Geriatrics Society. 38:19-24
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- Cerebrospinal fluid (CSF) somatostatin concentrations were measured in 35 aged patients with Parkinson's disease (mean age, 79.5 years) and 11 control subjects (mean age, 82.3 years). In patients with Parkinson's disease the levels of somatostatin-like immunoreactivity were lower than in controls (P less than .02); these values were lowest in the untreated group. Somatostatin-like immunoreactivity levels in the CSF tended to increase with treatment but not significantly (P = .11). Somatostatin values were not correlated to age, sex, or duration of the disease. Somatostatin concentrations tended to be lower in more severely affected patients with higher scores on the Hoehn and Yahr (P = .13) and Webster staging scales (P = .13) and lower scores on Mini-Mental State (P = .10), but without statistical significance for these correlations.
- Subjects :
- Male
medicine.medical_specialty
Parkinson's disease
Somatostatin-like immunoreactivity
Severity of Illness Index
Levodopa
Benserazide
Cerebrospinal fluid
Statistical significance
Internal medicine
medicine
Humans
In patient
Bromocriptine
Aged
Aged, 80 and over
business.industry
Homovanillic Acid
Parkinson Disease
Hydroxyindoleacetic Acid
medicine.disease
Control subjects
Aged patients
Endocrinology
Somatostatin
Female
Geriatrics and Gerontology
Cognition Disorders
business
Subjects
Details
- ISSN :
- 00028614
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of the American Geriatrics Society
- Accession number :
- edsair.doi.dedup.....5f46d607fad508a2419e33428891be54