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Sequential tumor and dual immune targeted immunotherapy: anti-lymphoma activity of Rituximab with 4-1bb stimulation and PD-1 blockade

Authors :
Jonathan Hebb
Holbrook E Kohrt
Roch Houot
Debra K. Czerwinski
Amanda Rajapaksa
Serena Chang
Cariad Chester
Ronald Levy
Mohith Sadaram
Erin Waller
Aurélien Marabelle
Idit Sagiv-Barfi
Antonia Ms Mueller
Source :
Journal for Immunotherapy of Cancer
Publisher :
Springer Nature

Abstract

Meeting abstracts To select maximally-efficacious, minimally-toxic regimens of combination tumor- and immune-targeted therapy, preclinical testing in immune-competent models is required. We previously demonstrated 4-1bb(CD137) stimulation augmented the innate immune response mediated by CD137+

Details

Language :
English
ISSN :
20511426
Volume :
2
Issue :
Suppl 3
Database :
OpenAIRE
Journal :
Journal for ImmunoTherapy of Cancer
Accession number :
edsair.doi.dedup.....5f46227b2c5f9d9275aa93bbffe2bb01
Full Text :
https://doi.org/10.1186/2051-1426-2-s3-p106