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Diagnosing and treating rare lesions in a low resource setting: lessons from ahybrid epithelioid trophoblastic tumor and choriocarcinoma
- Source :
- Scopus-Elsevier, Ghana Medical Journal; Vol 51, No 4 (2017); 196-199
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Abstract
- Objective: To raise awareness of the existence of a rare type of malignant trophoblastic tumor and discuss the diagnostic challenges and management of this lesion in a low resource setting.Case report and intervention: A 35 -year -old G6P3 woman was referred to our facility on account of persistent vaginal bleeding due to a suspected incomplete miscarriage with a cervical mass. Her serum β-HCG was elevated (36,900 mIU/ml) and examination showed a bleeding cervical mass. An initial histopathological diagnosis of moderately differentiated squamous cell carcinoma was reviewed to epithelioid trophoblastic tumor resulting in an extra-fascial hysterectomy. A final histopathological diagnosis of hybrid Epithelioid Trophoblastic Tumor and Choriocarcinoma (ETT/CC) was made after external review and immunohistochemistry. She received subsequent chemotherapy.Conclusion: Epithelioid trophoblastic tumor and its hybrids are difficult to diagnose. They may be diagnosed as moderately differentiated squamous cell carcinoma especially in low resource settings where cervical squamous cell carcinoma is relatively more common. A high index of suspicion, a serum β HCG test and close collaborationbetween clinicians and pathologists can help make the diagnosis.Funding: NoneKeywords: Epithelioid trophoblastic tumour, choriocarcinoma, diagnostic challenges, low resource setting
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
medicine.medical_treatment
Trophoblastic Tumor
Case Report
Trophoblastic Neoplasms
Hysterectomy
Lesion
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Drug Therapy
Pregnancy
Medicine
Humans
Vaginal bleeding
Chorionic Gonadotropin, beta Subunit, Human
Choriocarcinoma
Epithelioid Trophoblastic Tumor
reproductive and urinary physiology
Chemotherapy
business.industry
Epithelioid trophoblastic tumour
choriocarcinoma
diagnostic challenges
low resource setting
medicine.disease
Immunohistochemistry
030104 developmental biology
030220 oncology & carcinogenesis
embryonic structures
Uterine Neoplasms
Female
Radiology
Uterine Hemorrhage
medicine.symptom
business
Subjects
Details
- ISSN :
- 00169560
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Ghana Medical Journal; Vol 51, No 4 (2017); 196-199
- Accession number :
- edsair.doi.dedup.....5f4230084c8db5814717f2bfd628ef64