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A polymorphism withinErbB4is associated with risk for hepatocellular carcinoma in Chinese population
- Source :
- World Journal of Gastroenterology. 18:383
- Publication Year :
- 2012
- Publisher :
- Baishideng Publishing Group Inc., 2012.
-
Abstract
- AIM: To investigate the association between hepatocellular carcinoma (HCC) susceptibility and a 12-bp insertion/deletion polymorphism (rs6147150) in the 3’UTR of ErbB4. METHODS: Using a case-control design, the rs6147150 genotypes in 270 patients with HCC and 270 healthy controls were determined by direct polymerase chain reaction and polyacrylamide gel electrophoresis. Logistic regression was used to analyze the association between the polymorphism and cancer risk. RESULTS: Computational modeling suggested that rs6147150 was located in the seed region of hsa-let-7c, a potential target sequence in ErbB4 3’UTR. Logistic regression analysis showed that, compared with individuals homozygous for wild-type, heterozygotes [adjusted odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.03-2.17, P = 0.034] and individuals homozygous for 12-bp del/del (OR = 2.50, 95% CI = 1.37-4.56, P = 0.001) were at significantly higher risk of HCC. Carriers of the “del” allele of rs6147150 had a 1.59-fold increased risk for HCC (95% CI = 1.22-2.07, P = 0.003). CONCLUSION: rs6147150 may be associated with HCC risk, in part through let-7c-mediated regulation, and may be involved in the pathogenesis of HCC in Chinese populations.
- Subjects :
- Adult
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Receptor, ErbB-4
Brief Article
Logistic regression
Gastroenterology
Asian People
Internal medicine
Genotype
Humans
Medicine
Genetic Predisposition to Disease
Allele
3' Untranslated Regions
Alleles
Genetics
Polymorphism, Genetic
business.industry
Liver Neoplasms
Case-control study
Heterozygote advantage
General Medicine
Odds ratio
Middle Aged
medicine.disease
digestive system diseases
Confidence interval
ErbB Receptors
MicroRNAs
Case-Control Studies
Hepatocellular carcinoma
Female
business
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....5f24b47a28084f29be7760993b6e90dd