Additional file 1: Figure S1. of Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET

Multiple VOI settings on coronal fusion image of 18F-FMISO PET (window level 0–3 in SUV) and TBF PET (window level 0–80 ml/100 mL/min). VOIs (1-mm sphere) were manually placed over the entire tumor where there is an uptake of 18F-FMISO or TBF on the fusion PET images. Figure S2. Relationships between the 18F-FMISO SUV and quantitative values of TBF, TMRO2, OEF, and TBV of each tumor. Decreased trend of TBF and TBV, increased trend of OEF, and stable TMRO2 against the increase of 18F-FMISO SUV were observed. (DOC 673 kb)