Back to Search
Start Over
Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging
- Source :
- Journal of the American Chemical Society, Journal of the American Chemical Society, American Chemical Society, 2007, 129 (16), pp.5076-84. ⟨10.1021/ja068356j⟩, HAL, Journal of the American Chemical Society, American Chemical Society, 2007, pp.5076-5084, Journal of the American Chemical Society, American Chemical Society, 2007, 129 (16), pp.5076-84. 〈10.1021/ja068356j〉, Journal of the American Chemical Society, 2007, 129 (16), pp.5076-84. ⟨10.1021/ja068356j⟩
- Publication Year :
- 2007
- Publisher :
- HAL CCSD, 2007.
-
Abstract
- International audience; Luminescent hybrid nanoparticles with a paramagnetic Gd2O 3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
- Subjects :
- Fluorescence-lifetime imaging microscopy
MESH : Siloxanes
Nanoparticle
Contrast Media
Gadolinium
02 engineering and technology
[SPI.MAT] Engineering Sciences [physics]/Materials
MESH : Gadolinium
01 natural sciences
Biochemistry
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Polyethylene Glycols
MESH: Magnetic Resonance Imaging
[SPI.MAT]Engineering Sciences [physics]/Materials
Paramagnetism
Mice
Colloid and Surface Chemistry
Nuclear magnetic resonance
Heterocyclic Compounds
MESH: Animals
Lung
medicine.diagnostic_test
Chemistry
MESH : Rats
MESH : Polyethylene Glycols
MESH : Mice, Nude
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
Liver
Covalent bond
MESH : Organometallic Compounds
0210 nano-technology
Preclinical imaging
MESH : Fluorescence
Siloxanes
MESH: Rats
MESH: Heterocyclic Compounds
MESH : Lung
Mice, Nude
[SDV.CAN]Life Sciences [q-bio]/Cancer
010402 general chemistry
Catalysis
Fluorescence
[SDV.CAN] Life Sciences [q-bio]/Cancer
MESH : Magnetic Resonance Imaging
MESH: Contrast Media
PEG ratio
MESH : Mice
medicine
Organometallic Compounds
MESH: Mice, Nude
Animals
MESH: Lung
MESH: Siloxanes
MESH: Mice
MESH : Contrast Media
MESH: Fluorescence
MESH : Liver
Magnetic resonance imaging
MESH: Organometallic Compounds
General Chemistry
0104 chemical sciences
Rats
MESH : Heterocyclic Compounds
MESH: Polyethylene Glycols
MESH : Nanoparticles
Nanoparticles
MESH : Animals
Luminescence
MESH: Gadolinium
MESH: Nanoparticles
MESH: Liver
Subjects
Details
- Language :
- English
- ISSN :
- 00027863 and 15205126
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society, Journal of the American Chemical Society, American Chemical Society, 2007, 129 (16), pp.5076-84. ⟨10.1021/ja068356j⟩, HAL, Journal of the American Chemical Society, American Chemical Society, 2007, pp.5076-5084, Journal of the American Chemical Society, American Chemical Society, 2007, 129 (16), pp.5076-84. 〈10.1021/ja068356j〉, Journal of the American Chemical Society, 2007, 129 (16), pp.5076-84. ⟨10.1021/ja068356j⟩
- Accession number :
- edsair.doi.dedup.....5ee741418d157228bc514a0dc551767a