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Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure
- Source :
- Journal of Reproductive Immunology. 124:62-70
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Thyroid autoimmunity (TAI) appears to play a crucial role in female infertility, recurrent pregnancy loss and IVF failure. Thyroid autoantibodies against thyroid peroxidase and thyroglobulin have been shown to represent an independent risk factor for infertility and miscarriage. Moreover, thyroxin hormone administration reduces the risk of obstetrical complications in TAI positive women. The aim of our present study was to investigate the immunological background of female infertility and recurrent pregnancy loss in euthyroid and subclinical hypothyroid women with TAI focusing on innate immunity. Phenotypic and functional analysis was carried out on peripheral blood mononuclear cells from healthy donors and TAI patients by flow cytometry. Our findings show Th1 oriented changes of innate immunity in the peripheral blood of women suffering from thyroid autoimmunity. Elevated NK and NKT-like cells ratios and enhanced natural cytotoxicity of TAI positive women reveal an altered immune status with possible negative impact on pregnancy outcome. It is important to notice that immune alterations are already established in the euthyroid phase of autoimmune thyroiditis before endocrine dysfunction develops and only the presence of thyroid autoantibodies indicate TAI condition. For this reason, screening of healthy women of reproductive age for the presence of thyroid autoantibodies would be beneficial not only from the endocrinological aspect but from the reproductive point of view since, although yet unexplained, thyroid hormone administration may improve pregnancy outcome.
- Subjects :
- Adult
Cytotoxicity, Immunologic
Risk
0301 basic medicine
Infertility
Abortion, Habitual
endocrine system
endocrine system diseases
medicine.medical_treatment
Immunology
Immunophenotyping
Autoimmune thyroiditis
03 medical and health sciences
0302 clinical medicine
Hypothyroidism
Pregnancy
Thyroid peroxidase
medicine
Humans
Immunology and Allergy
Euthyroid
Cells, Cultured
Autoantibodies
Blood Cells
030219 obstetrics & reproductive medicine
biology
business.industry
Female infertility
Thyroid
Pregnancy Outcome
Thyroiditis, Autoimmune
Obstetrics and Gynecology
Th1 Cells
medicine.disease
Immunity, Innate
Anti-thyroid autoantibodies
Killer Cells, Natural
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
Asymptomatic Diseases
biology.protein
Cytokines
Natural Killer T-Cells
Female
Thyroglobulin
business
Subjects
Details
- ISSN :
- 01650378
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Journal of Reproductive Immunology
- Accession number :
- edsair.doi.dedup.....5ee497aace19a0071dd28b7a846034bd