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Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells
- Source :
- Haematologica. 94(9):1301-1309
- Publication Year :
- 2009
- Publisher :
- FERRATA STORTI FOUNDATION, 2009.
-
Abstract
- 金沢大学医薬保健研究域医学系<br />Translocation of chromosomes 8 and 21, t(8;21), resulting in the AML1-ETO fusion gene, is associated with acute myeloid leukemia. We searched for additional genomic abnormalities in this acute myeloid leukemia subtype by performing single nucleotide polymorphism genomic arrays (SNP-chip) analysis on 48 newly diagnosed cases. Thirty-two patients (67%) had a normal genome by SNP-chip analysis (Group A), and 16 patients (33%) had one or more genomic abnormalities including copy number changes or copy number neutral loss of heterozygosity (Group B). Two samples had copy number neutral loss of heterozygosity on chromosome 6p including the PIM1 gene; and one of these cases had E135K mutation of Pim1. Interestingly, 38% of Group B and only 13% of Group A samples had a KIT-D816 mutation, suggesting that genomic alterations are often associated with a KIT-D816 mutation. Importantly, prognostic analysis revealed that overall survival and event-free survival of individuals in Group B were significantly worse than those in Group A. ©2009 Ferrata Storti Foundation.
- Subjects :
- Myeloid
Oncogene Proteins, Fusion
Chromosomes, Human, Pair 21
Mutation, Missense
Loss of Heterozygosity
SNP-chip
Chromosomal translocation
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Disease-Free Survival
Translocation, Genetic
Loss of heterozygosity
RUNX1 Translocation Partner 1 Protein
Proto-Oncogene Proteins c-pim-1
hemic and lymphatic diseases
medicine
Tumor Cells, Cultured
Missense mutation
Humans
AML1-ETO
neoplasms
t(8
21)
Oligonucleotide Array Sequence Analysis
Genetics
Genome, Human
Myeloid leukemia
KIT
Hematology
medicine.disease
Molecular biology
Survival Rate
Leukemia
Leukemia, Myeloid, Acute
Proto-Oncogene Proteins c-kit
PIM1
medicine.anatomical_structure
Core Binding Factor Alpha 2 Subunit
Brief Reports
CNN-LOH
Virtual karyotype
Chromosomes, Human, Pair 8
Subjects
Details
- Language :
- English
- ISSN :
- 03906078
- Volume :
- 94
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.doi.dedup.....5ee3df80775e4ea1f479ab4cd52ac738