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Brain-derived neurotrophic factor is related with adverse cardiac remodeling and high NTproBNP
- Source :
- Scientific Reports, Scientific reports 9(1), 15421 (2019). doi:10.1038/s41598-019-51776-8, Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- The brain-derived neurotrophic factor (BDNF) is a neuronal growth factor essential for normal cardiac contraction and relaxation. Alterations in BDNF signaling are related to the development of cardiovascular disease. Whether BDNF is related to subclinical cardiac remodeling is unclear. We related BDNF with echocardiographic parameters and NTproBNP in a large population-based cohort (n = 2,976, median age 48 years; 45% male). Transthoracic echocardiography was performed on all subjects and BDNF was measured by ELISA. Study participants with severe kidney dysfunction, previous myocardial infarction, and LV ejection fraction
- Subjects :
- Adult
Male
medicine.medical_specialty
Cardiology
lcsh:Medicine
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
blood [Natriuretic Peptide, Brain]
Neurotrophic factors
blood [Cardiovascular Diseases]
Internal medicine
Natriuretic Peptide, Brain
medicine
Humans
Myocardial infarction
lcsh:Science
Subclinical infection
Brain-derived neurotrophic factor
diagnostic imaging [Cardiovascular Diseases]
Multidisciplinary
Ejection fraction
Ventricular Remodeling
business.industry
lcsh:R
Stroke Volume
Middle Aged
medicine.disease
Myocardial Contraction
Peptide Fragments
Blood pressure
nervous system
blood [Peptide Fragments]
Cardiovascular Diseases
Echocardiography
Cohort
Lean body mass
lcsh:Q
Female
business
ddc:600
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....5ed41b7def3b461442f162176e68a0a7