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Supplemental Tables 1-5 and Legend to Supplemental Figure 1 from A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer

Authors :
Joellen M. Schildkraut
Jennifer A. Doherty
Kenneth Muir
Zsofia Kote-Jarai
Ros Eeles
Doug F. Easton
Kevin McDonnell
Amit D. Joshi
Judy E. Garber
David J. Hunter
Stephen B. Gruber
Brian E. Henderson
Paul Pharoah
John S. Witte
Thomas A. Sellers
Rayjean J. Hung
Peter Kraft
Christopher I. Amos
Yonathan Brhane
Edwin S. Iversen
Rachel Palmieri Weber
Peter M. Scarbrough
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplemental Table 1: Detailed characteristics of studies included in the ASSET meta-analysis of DNA damage repair and signaling genes. Supplemental Table 2: DNA repair gene, region, and final SNP selection data, using human reference genome assembly, GRCh38. Supplemental Table 3: List of all DNA repair genes and DNA repair pathways included in this study. Supplemental Table 4: Statistical associations (p-values) for cancer risk versus genetic variation within DNA repair pathways. Sensitivity analysis of Table 3, with RAD51B, MSH5, and BRCA2 gene removed from analysis. Statistically significant values are in bold (p < 0.05). Supplemental Table 5: Statistical associations (p-values) for cancer risk versus genetic variation within DNA repair pathways. Sensitivity analysis of Table 3, with 6 genes removed from the analysis -- all genes containing loci with individual SNP associations of p < 1 x 10-4. Statistically significant values are in bold (p < 0.05).

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....5ecd136935e2192d184c4cdb9cf94967