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Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy
- Source :
- Clin Pharmacol Ther, Clinical Pharmacology and Therapeutics (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have been studied for an association with the clinical effect and safety of these drugs. Other genes that have been studied for their association with opioid clinical effect or adverse events include OPRM1 (mu receptor) and COMT (catechol-O-methyltransferase). This guideline updates and expands the 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and codeine therapy and includes a summation of the evidence describing the impact of CYP2D6, OPRM1, and COMT on opioid analgesia and adverse events. We provide therapeutic recommendations for the use of CYP2D6 genotype results for prescribing codeine and tramadol and describe the limited and/or weak data for CYP2D6 and hydrocodone, oxycodone, and methadone, and for OPRM1 and COMT for clinical use.
- Subjects :
- medicine.medical_specialty
Genotype
Pharmacogenomic Variants
Receptors, Opioid, mu
Pain
Catechol O-Methyltransferase
digestive system
030226 pharmacology & pharmacy
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
skin and connective tissue diseases
Pharmacology
ddc:617
business.industry
Codeine
Guideline
Pharmacogenomic Testing
Analgesics, Opioid
Cytochrome P-450 CYP2D6
Hydrocodone
Opioid
030220 oncology & carcinogenesis
Tramadol
business
Oxycodone
Pharmacogenetics
medicine.drug
Methadone
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....5ec025355c1679cbc2986e0e2e94990d
- Full Text :
- https://doi.org/10.1002/cpt.2149