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Unified approaches to assessing treatment effect of traditional Chinese medicine based on health profiles
- Source :
- Journal of biopharmaceutical statistics. 30(3)
- Publication Year :
- 2020
-
Abstract
- Two dissimilarity indices are introduced to measure the disharmony of a human body system by mimicking the population bioequivalence and the individual bioequivalence concepts. Hypotheses for the treatment effect of a traditional Chinese medicine are formulated based on the two indices and then tested under the proposed designs by reverting an approximate confidence upper bound. The proposed methods can also be used when a drug product has multiple components or a trial has multiple endpoints.
- Subjects :
- Statistics and Probability
Population
Traditional Chinese medicine
Bioequivalence
01 natural sciences
Upper and lower bounds
010104 statistics & probability
03 medical and health sciences
0302 clinical medicine
Statistics
Humans
Pharmacology (medical)
Treatment effect
030212 general & internal medicine
0101 mathematics
Medicine, Chinese Traditional
education
Biosimilar Pharmaceuticals
Mathematics
Pharmacology
Body system
Measure (data warehouse)
education.field_of_study
Principal Component Analysis
Treatment Outcome
Therapeutic Equivalency
Principal component analysis
Subjects
Details
- ISSN :
- 15205711
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of biopharmaceutical statistics
- Accession number :
- edsair.doi.dedup.....5eaf534710e3e25d4447d3d1bb179425