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The cholinergic nature of the cercal nerve-giant fiber synapse in the sixth abdominal ganglion of the American cockroach,Periplaneta americana (L.)
The cholinergic nature of the cercal nerve-giant fiber synapse in the sixth abdominal ganglion of the American cockroach,Periplaneta americana (L.)
- Source :
- Journal of Neurobiology. 2:247-262
- Publication Year :
- 1971
- Publisher :
- Wiley, 1971.
-
Abstract
- The effects of cholinergic drugs on transmission at the cercal nervegiant fiber synapse in the desheathed sixth abdominal ganglion of the American cockroach, Periplaneta americana (L.) were evaluated. When due consideration was given to slow diffusion rates of drugs into the ganglion, and to the enzymic hydrolysis of exogenously applied choline esters by endogenous cholinesterase, the synapse was found to respond in ways consistent with cholinergic transmission. Botulinus toxin, magnesium, and hemicholinium-3, all working presynaptically blocked transmission. Atropine, D-tubocurarine, and hexamethonium produced non-depolarizing blockade at concentrations of 10−7M or 10−6M. Atropine and d-tubocurarine also blocked the action of exogenously applied acetylcholine. Postsynaptic responses were obtained from acetylcholine (10−7M), acetyl s-methyl choline (10−8M), and nicotine (10−8M). The results were discussed with respect to criteria which have been proposed for the indentification of transmitters. It was concluded that considering all of the information available on the cercal nerve-giant fiber synapse, the transmitter is almost certainly Ach.
- Subjects :
- Atropine
medicine.medical_specialty
Botulinum Toxins
Sensory Receptor Cells
Decamethonium Compounds
Action Potentials
Tubocurarine
Cockroaches
Hexamethonium Compounds
Synaptic Transmission
Synapse
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Postsynaptic potential
Internal medicine
Abdomen
medicine
Animals
Magnesium
Cholinesterase
Neurotransmitter Agents
biology
General Neuroscience
Hemicholinium 3
biology.organism_classification
Acetylcholine
Endocrinology
chemistry
Synapses
biology.protein
Cholinergic
Calcium
Ganglia
Hexamethonium
American cockroach
medicine.drug
Periplaneta
Subjects
Details
- ISSN :
- 10974695 and 00223034
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Neurobiology
- Accession number :
- edsair.doi.dedup.....5ea42502f60114c3b45aab308b9add87
- Full Text :
- https://doi.org/10.1002/neu.480020306