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PLA-PEG Micelles Loaded with a Classic Vasodilator for Oxidative Cataract Prevention
- Source :
- ACS biomaterials scienceengineering. 5(2)
- Publication Year :
- 2021
-
Abstract
- The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA–PEG to form NFP-loaded PLA–PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage. The NFP-loaded PLA–PEG micelles not only showed satisfactory biocompatibility and bioavailability, but also efficiently improved the anticataract ability through the inhibition of extracellular calcium ions influx. This study may provide a new insight into the development of cataract treatment.
- Subjects :
- genetic structures
Biocompatibility
medicine.drug_class
medicine.medical_treatment
0206 medical engineering
Biomedical Engineering
chemistry.chemical_element
macromolecular substances
02 engineering and technology
Calcium channel blocker
Calcium
Pharmacology
medicine.disease_cause
Micelle
Biomaterials
Nifedipine
medicine
technology, industry, and agriculture
Eye drop
021001 nanoscience & nanotechnology
020601 biomedical engineering
eye diseases
Bioavailability
chemistry
sense organs
0210 nano-technology
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 23739878
- Volume :
- 5
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- ACS biomaterials scienceengineering
- Accession number :
- edsair.doi.dedup.....5ea051dff16ba93972750976b3e3dfc3