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Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

Authors :
Dichgans, M.
Malik, R.
Konig, I. R.
Rosand, J.
Clarke, R.
Gretarsdottir, S.
Thorleifsson, G.
Mitchell, B. D.
Assimes, T. L.
Levi, C.
O'Donnell, C. J.
Fornage, M.
Thorsteinsdottir, U.
Psaty, B. M.
Hengstenberg, C.
Seshadri, S.
Erdmann, J.
Bis, J. C.
Peters, A.
Boncoraglio, G. B.
Marz, W.
Meschia, J. F.
Kathiresan, S.
Ikram, M. A.
McPherson, R.
Stefansson, K.
Sudlow, C.
Reilly, M. P.
Thompson, J. R.
Sharma, P.
Hopewell, J. C.
Chambers, J. C.
Watkins, H.
Rothwell, P. M.
Roberts, R.
Markus, H. S.
Samani, N. J.
Farrall, M.
Schunkert, H.
Gschwendtner, A.
Bevan, S.
Chen, Y.-C.
DeStefano, A. L.
Parati, E. A.
Quertermous, T.
Ziegler, A.
Boerwinkle, E.
Holm, H.
Fischer, M.
Kessler, T.
Willenborg, C.
Laaksonen, R.
Voight, B. F.
Stewart, A. F. R.
Rader, D. J.
Hall, A. S.
Kooner, J. S.
Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (M.D., R. Malik)
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.)
Institut für Medizinische Biometrie und Statistik (I.R.K.), and Institut für integrative und experimentelle Genomik (J.E.), Universität zu Lübeck, Lübeck, Germany
Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany (I.R.K.)
Department of Neurology and Center for Human Genetic Research (J.R.), and Cardiology Division (C.J.O.D.), Massachusetts General Hospital, Boston
Harvard Medical School, Boston, MA (J.R.)
Program in Medical and Population Genetics (J.R.), and Program in Medical and Population Genetics (S.K.), Broad Institute of Harvard and MIT, Cambridge, MA
Clinical Trial Service Unit and Epidemiological Studies Unit (R.C., J.C.H.), Wellcome Trust Centre for Human Genetics (H.W., M. Farrall), Department of Cardiovascular Medicine (M. Farrall), and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience (P.M.R.), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
deCODE Genetics, Reykjavik, Iceland (S.G., G.T., U.T., K.S.)
Department of Medicine, University of Maryland School of Medicine, Baltimore (B.D.M.)
Department of Medicine, Stanford University School of Medicine, Stanford, CA (T.L.A.)
Center for Translational Neuroscience and Mental Health Research, University of Newcastle, New South Wales, Australia (C.L.)
Hunter Medical Research Institute, New South Wales, Australia (C.L.)
National Heart, Lung and Blood Institute and NHLBI's Framingham Heart Study, MA (C.J.O.D., S.S.)
University of Texas Health Science Center at Houston (M. Fornage)
Cardiovascular Health Research Unit, Department of Epidemiology (B.M.P.), Department of Medicine (B.M.P.), Department of Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Medicine (J.C.B.), University
Radiology & Nuclear Medicine
Source :
Stroke; Vol 45, Stroke, 45(1), 24-36. Lippincott Williams & Wilkins
Publication Year :
2014

Abstract

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P

Subjects

Subjects :
medicine.medical_specialty
Multifunction cardiogram
Áhættuþættir
Genome-wide association study
Coronary Artery Disease
Polymorphism, Single Nucleotide
Article
Brain Ischemia
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Heilablóðfall
Polymorphism (computer science)
Risk Factors
Internal medicine
medicine
Genetic predisposition
Humans
Genetic Predisposition to Disease
Stroke
030304 developmental biology
Advanced and Specialized Nursing
0303 health sciences
business.industry
Kransæðasjúkdómar
Reproducibility of Results
Heritability
Arfgengi
medicine.disease
Phenotype
Meta-analysis
Data Interpretation, Statistical
Cardiology
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Genome-Wide Association Study

Details

Language :
English
ISSN :
15244628, 00392499, and 26820110
Volume :
45
Issue :
1
Database :
OpenAIRE
Journal :
Stroke; a journal of cerebral circulation
Accession number :
edsair.doi.dedup.....5e8c805c3e2f4a2614fc1aca5491d25a

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