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An intracytoplasmic β3 Leu718 deletion in a patient with a novel platelet phenotype
- Source :
- Blood Advances, Blood Advances, 2017, 1 (8), pp.494-499. ⟨10.1182/bloodadvances.2016002808⟩, Blood Advances, The American Society of Hematology, 2017, 1 (8), pp.494-499. ⟨10.1182/bloodadvances.2016002808⟩
- Publication Year :
- 2016
-
Abstract
- Key Points A novel heterozygous ITGB3 Leu718del shows loss of synchronization between the intracytoplasmic tail of β3 with that of αIIb. Decreased activation of αIIbβ3 accompanies enlarged platelets that contain giant granules and give a poor aggregation response.
- Subjects :
- business.industry
Article RECHERCHE
Hematology
030204 cardiovascular system & hematology
Biology
Phenotype
Stimulus Report
Cell biology
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
03 medical and health sciences
0302 clinical medicine
Text mining
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Synchronization (computer science)
Immunology
Platelet
business
030215 immunology
Enlarged platelets
Subjects
Details
- ISSN :
- 24739529 and 24739537
- Volume :
- 1
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Blood advances
- Accession number :
- edsair.doi.dedup.....5e7f305cdcdcce880ccfaa79f0ed1ea4
- Full Text :
- https://doi.org/10.1182/bloodadvances.2016002808⟩