Back to Search
Start Over
Elevated heart rate at 24–36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure
- Source :
- International Journal of Cardiology, International Journal of Cardiology, Elsevier, 2015, 182, pp.426-430. ⟨10.1016/j.ijcard.2015.01.027⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- article i nfo Background: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36 h after admission for acute non-arrhythmic HF and in- hospital mortality. Methods and results: We examined the association of heart rate with in-hospital mortality in a cohort of 712 pa- tients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78 ± 9 vs. 72 ± 12 years; p = 0.0021), had higher heart rate (92 ± 22 vs. 78 ± 18 bpm; p b 0.0001), NT pro-BNP (p = 0.0005), creatinine (p = 0.023), were often diabetics (p = 0.026) and had lower systolic and diastolic blood pressures (p b 0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p b 0.01). With multivariable analysis, age (p = 0.037), heart rate (p b 0.0001), diastolic blood pressure (p b 0.001), prior ischemic heart disease (p = 0.02) and creatinine (p = 0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p = 0.007). Conclusions: Higher heart rate 24-36 h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge.
- Subjects :
- Male
medicine.medical_specialty
Acute coronary syndrome
Time Factors
Rest
Heart rate
Diastole
Heart failure
Risk Assessment
chemistry.chemical_compound
Patient Admission
Belgium
Internal medicine
medicine
Humans
Hospital Mortality
Risk stratification
Aged
Retrospective Studies
Outcome
Inpatients
Creatinine
business.industry
Mortality rate
Prognosis
medicine.disease
3. Good health
Treatment
Blood pressure
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Cohort
Electrocardiography, Ambulatory
Cardiology
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 01675273 and 18741754
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology, International Journal of Cardiology, Elsevier, 2015, 182, pp.426-430. ⟨10.1016/j.ijcard.2015.01.027⟩
- Accession number :
- edsair.doi.dedup.....5e71ce1bf87986a0a6420e65b9d25212