Back to Search
Start Over
Vulnerability to depression: from brain neuroplasticity to identification of biomarkers
- Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(36)
- Publication Year :
- 2011
-
Abstract
- A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traits underlying the development of depressive disorders in adult animals. Four weeks after a priming stressful event, serum corticosterone concentration returned to control values in all animals, whereas the other biological parameters returned to basal level in only 58% of animals (called nonvulnerable). In contrast, 42% of animals displayed persistent decreased serum and hippocampus BDNF concentrations, reduced hippocampal volume and neurogenesis, CA3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. In this group, called vulnerable, a subsequent mild stress evoked a rise of serum corticosterone levels and a “depressive” phenotype, in contrast to nonvulnerable animals. Intracerebroventricular administration of 7,8-dihydroxyflavone, a selective TrkB receptor agonist, dampened the development of the “depressive” phenotype. Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression.
- Subjects :
- Male
medicine.medical_specialty
Competitive Behavior
Hypothalamo-Hypophyseal System
Imipramine
Hippocampus
Pituitary-Adrenal System
Tropomyosin receptor kinase B
Antidepressive Agents, Tricyclic
Social Environment
Amygdala
Rats, Sprague-Dawley
chemistry.chemical_compound
Basal (phylogenetics)
Corticosterone
Internal medicine
Neuroplasticity
medicine
Animals
Longitudinal Studies
Depression (differential diagnoses)
Swimming
Cell Proliferation
Neurons
Depressive Disorder
Neuronal Plasticity
General Neuroscience
Brain-Derived Neurotrophic Factor
Neurogenesis
Brain
Articles
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Taste
Psychology
Neuroscience
Biomarkers
Stress, Psychological
Subjects
Details
- ISSN :
- 15292401
- Volume :
- 31
- Issue :
- 36
- Database :
- OpenAIRE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Accession number :
- edsair.doi.dedup.....5e650299e7230bc5a16820fe6670699d