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Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study
- Source :
- Cancers, Volume 13, Issue 15, Cancers, Vol 13, Iss 3901, p 3901 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The effect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesions was related to the histopathological responses in the main part of the tumor. Complete disappearance of the tail-like lesion was observed in 12 patients<br />however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with and without the complete disappearance of tail-like lesions. This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
chemotherapy
tail-like lesion
Article
Undifferentiated Pleomorphic Sarcoma
Lesion
03 medical and health sciences
0302 clinical medicine
medicine
invasive front
neoadjuvant therapy
RC254-282
radiotherapy
Neoadjuvant therapy
Chemotherapy
business.industry
allergology
Soft tissue sarcoma
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Soft tissue
Retrospective cohort study
medicine.disease
Radiation therapy
undifferentiated pleomorphic sarcoma
030104 developmental biology
Oncology
soft tissue sarcoma
030220 oncology & carcinogenesis
myxofibrosarcoma
Sarcoma
Radiology
medicine.symptom
business
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....5e5de7c5c01a9a4c0e5635de2c5a9ec4