Back to Search
Start Over
Synthesis of 2-((2-(Benzo[d]oxazol-2-yl)-2H-imidazol-4-yl)amino)-phenols from 2-((5H-1,2,3-Dithiazol-5-ylidene)amino)phenols through Unprecedented Formation of Imidazole Ring from Two Methanimino Groups
Synthesis of 2-((2-(Benzo[d]oxazol-2-yl)-2H-imidazol-4-yl)amino)-phenols from 2-((5H-1,2,3-Dithiazol-5-ylidene)amino)phenols through Unprecedented Formation of Imidazole Ring from Two Methanimino Groups
- Source :
- Molecules, Volume 25, Issue 17, Molecules, Vol 25, Iss 3768, p 3768 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- A new synthetic pathway to four substituted imidazoles from readily available 2-((4-aryl(thienyl)-5H-1,2,3-dithiazol-5-ylidene)amino)phenols has been developed. Benzo[d]oxazol-2-yl(aryl(thienyl))methanimines were proved as key intermediates in their synthesis. The formation of an imidazole ring from two methanimine derivatives likely includes the opening of one benzoxazole ring followed by ring closure by intermolecular nucleophilic attack of the N-methanimine atom to a carbon atom of another methanimine.
- Subjects :
- Models, Molecular
Pharmaceutical Science
Ring (chemistry)
Crystallography, X-Ray
Medicinal chemistry
Article
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
Nucleophile
Phenols
lcsh:Organic chemistry
sulfur-nitrogen heterocycles
Drug Discovery
5-Arylimino-1,2,3-dithiazoles
Imidazole
Physical and Theoretical Chemistry
X ray analysis
Benzoxazoles
Carbon atom
Molecular Structure
Aryl
Organic Chemistry
Imidazoles
thermolysis
Benzoxazole
chemistry
Chemistry (miscellaneous)
Molecular Medicine
four substituted 2H-imidazol-4-amines
Imines
X-ray analysis
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....5e2fce5feb994fef0939b0ec69efa959
- Full Text :
- https://doi.org/10.3390/molecules25173768