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The effects of intraocular pressure elevation on optic nerve axonal transport in the monkey
- Source :
- Acta Ophthalmologica. 68:37-43
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Blockage of axonal transport by intraocular pressure (IOP) elevation was studied quantitatively in monkey eyes, using liquid scintillation counting. After 5 h of IOP elevation (perfusion pressure of 30 mmHg), axonally transported protein was measured in the distal third of each optic nerve, which was divided into superotemporal, inferotemporal, superonasal, and inferonasal portions. The ratio of the amount of radioactive protein in each portion of the optic nerve to that in the whole optic nerve was calculated. In eyes with IOP elevation, the mean ratio for the temporal optic nerve was significantly lower than that for the nasal optic nerve. It appeared that axonal transport was not affected homogenously throughout the optic nerve but was more impaired in the temporal half of the optic nerve following IOP elevation.
- Subjects :
- Nervous system
Intraocular pressure
genetic structures
Optic Disk
Axonal Transport
medicine
Animals
Tissue distribution
Eye Proteins
Intraocular Pressure
Analysis of Variance
business.industry
Optic Nerve
General Medicine
Anatomy
eye diseases
Distal third
Perfusion
Ophthalmology
medicine.anatomical_structure
Optic nerve
Axoplasmic transport
Autoradiography
Macaca
Scintillation Counting
ON - Optic nerve
sense organs
business
Subjects
Details
- ISSN :
- 1755375X
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Acta Ophthalmologica
- Accession number :
- edsair.doi.dedup.....5e292e9810a2029cd698d4ea439609e3